MYELOID NEOPLASIA Clinical relevance of Wilms tumor 1 gene mutations in childhood acute myeloid leukemia
نویسندگان
چکیده
1Department of Pediatric Oncology/Hematology, Erasmus MC–Sophia Children’s Hospital, Rotterdam, The Netherlands; 2AML-BFM Study Group, Department of Pediatric Oncology/Hematology, Medical High School, Hannover, Germany; 3Clincial Genetics, Academic Medical Center, Amsterdam, The Netherlands; 4Department of Hematology and Oncology, University Children’s Hospital of Frankfurt, Frankfurt, Germany; 5Department of Pediatric Oncology/Hematology, VU University Medical Center, Amsterdam, The Netherlands; 6Pediatric Haematology/Oncology, Second Medical School, Charles University Prague, Prague, Czech Republic; 7Hematology, Saint-Louis Hospital, Paris, France; 8Department of Pediatric Oncology/Hematology, Radboud University Medical Center, Nijmegen, The Netherlands; and 9AML-BFM Study Group, University Children’s Hospital, Münster, Germany
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متن کاملWilms' tumor (WT1) gene mutations occur mainly in acute myeloid leukemia and may confer drug resistance.
In a previous study of acute leukemia, we have shown that WT1 gene mutations occur in both myeloid and biphenotypic subtypes, where they are associated with refractoriness to standard induction chemotherapy. We have now extended this study to a total of 67 cases (34 acute myeloid leukemia [AML], 23 acute lymphoblastic leukemia [ALL], 10 acute undifferentiated leukemia [AUL]/biphenotypic) and fi...
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متن کاملWilms’ Tumor (WT1) Gene Mutations Occur Mainly in Acute Myeloid Leukemia and May Confer Drug Resistance
In a previous study of acute leukemia, we have shown that WT1 gene mutations occur in both myeloid and biphenotypic subtypes, where they are associated with refractoriness to standard induction chemotherapy. We have now extended this study to a total of 67 cases (34 acute myeloid leukemia [AML], 23 acute lymphoblastic leukemia [ALL], 10 acute undifferentiated leukemia [AUL]/biphenotypic) and fi...
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